Director, Statistical Programming

The Opportunity Maze is looking for a Director of Statistical Progr ammi ng , who will help shap e the data foundation of our clinical development programs . In thi s role y ou’ll collaborate closely with colleagues across Biostatistics, Clinical Data Management, Clinical Operations, and Regulatory Affairs, and oversee external vendors to keep our studies rigorous, high-quality, and ready for regulatory review . You’ll report to the Vice President of Biometrics and lead the stra tegy and day-to-day execution of statistical programmi ng across multiple clinical studies . You r leadership will ensure we deliver reliable, efficient , and regulatory-c ompliant programming outputs that drive smarter decisions and ad vance our therapeutic programs. The Impact You’ll Have • Define and implement statistical programming strategy , standards, and best practices across development programs . • Lead the design, development, validation , and maintenance of SAS macros, scripts, and applications supporting clinical data analysis, reporting, and regulatory deliverables (e.g., SDTM, ADaM datasets, TLFs) . • Ensure programming infrastructure is robust , scalable, and compliant with regulatory standards (e.g., FDA 21 CFR Part 11, GxP ), and supports reproducibility and audit readiness . • Drive automation and standardization of programming workflows to improve efficiency and consistency across studies . • Partner closely with Biostatistics, Clinical Data Management, Regulatory Affairs , and IT to define programming requirements, align on analysis/reporting deliverables, and ensure data integrity . • Represent the statistical programming function in cross-functional meetings and strategic initiatives . • Manage CROs and external programming vendors , including scope, timelines, quality, and budget oversight . • Support outsourcing strategy and vendor selection As a Director , we also expect you to demonstrate the following Leadership Competencies: • Communication and Influence • Builds communication channels across Maze for sharing information. • Influences Senior Management decisions through persuasive arguments. • Respectfully addresses differing opinions leading to support of decisions. • Teamwork and Collaboration • Champions partnerships and connections across Maze. • Proactively addresses issues that could result in breakdown of team relationships. • Spotlights team and individual contributions in public forums. • Execution and Results • Addresses gaps and leverages strengths to get best results. • Maintains a steadying presence and clarifies priorities during change. • Anticipates and removes barriers that put functional/corporate goals at risk. • Develop Others and Self • Remove barriers to staff development and empowers them to make their own decisions. • Stays current on industry trends and keeps direct-reports prepared and responsive. What We’re Looking For • An advanced degree in Statistics, Computer Science, Mathematics, or related discipline • Master’s degree with 10+ years of experience, or Ph.D. with 8+ years of experience • A track record of leading statistical programming efforts across multiple clinical studies or regulatory submissions. • Strong decision-making skills and the a bility to guide teams through ambiguity while influencing across project teams. • A collaborative leadership style that emphasizes mentorship, knowledge sharing, and developing others. • Deep technical expertise in statistical programming for clinical research, with familiarity in CDISC standards, submission ‑ ready deliverables, and modern programming best practices. This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week. About Maze Therapeutics Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease. Our People Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. Our Core Values Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. Stand True – Our integrity is foundational; it guides us no matter the obstacle. The expected annual salary range for employees located in the San Francisco Bay Area is $229, 000 - $279,000 . Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future. Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. #LI-Hybrid